Coverage for chemotherapy is determined according to individual or group customer benefits. The following chemotherapy services and supplies are covered in any place of service, if the patient has a malignant disease, the drug being used is FDA approved, and a doctor performed or supervised and billed for the service.
- NOTE:
- Chemotherapy for non-malignant disease may be paid as a therapeutic injection according to the member's benefits.
Off-Labeled Use for Anti-Cancer Drugs
For consideration of off-labeled use for anti-cancer drugs, the patient must have failed all approved first line therapies, or their condition precludes their use, and there are no other therapeutic options available.
An off-labeled use of a drug is a use that is not included as an indication on the drug's label as approved by the FDA. FDA approved drugs used for indications other than what is indicated on the official label may be covered if the use is determined to be medically acceptable, taking into consideration the major drug compendia, authoritative medical literature and/or accepted standards of the medical practice.
Off-labeled uses of FDA approved drugs and biologicals used in an anti-cancer chemotherapeutic regimen for a medically accepted indication are evaluated under the conditions described below. A cancer treatment regimen includes drugs used to treat toxicities or side effects of the cancer treatment regimen when the drug is administered incident to a chemotherapy treatment.
An off-label usage of an FDA approved drug will be considered for coverage when there are no specific contraindications and one of the following criteria is met.
- Its usage is supported by one or more citations in at least one of the drug compendia listed below, and the usage is not listed as "not indicated" in any of the compendia listed below:
- American Hospital Formulary Service Drug Information
- American Medical Association Drug Evaluations
- United States Pharmacopoeia Drug Information (USPDI)
- The use is supported by clinical research that appears in peer-reviewed medical literature. This applies only when an off-labeled use does not appear in any of the compendia or is listed as insufficient data or investigational. Peer-reviewed medical literature includes scientific, medical, and pharmaceutical publications in which original manuscripts are published, only after having been critically reviewed for scientific accuracy, validity, and reliability by unbiased independent experts. This does not include in-house publications of pharmaceutical manufacturing companies or abstracts (including meeting abstracts).
Coverage will be determined based on the results of peer-reviewed medical literature published in any of the following:
- American Journal of Medicine
- Annals of Internal Medicine
- The Journal of the American Medical Association
- Journal of Clinical Oncology
- Blood
- Journal of the National Cancer Institute
- The New England Journal of Medicine
- British Journal of Cancer
- British Journal of Hematology
- British Medical Journal
- Cancer
- Drugs
- European Journal of Cancer
- Lancet
- Leukemia
- Journal of Pediatric Hematology/Oncology
ITEM |
COVERAGE STATUS |
- I.
- Drugs
90586, A9600, A9605, J0128, J0640, J0780, J0881, J0882, J0885, J0886, J1094, J1100, J1190, J1200, J1260, J1440, J1441, J1457, J1626, J1675, J1720, J1940, J2060, J2150, J2278, J2353, J2354, J2355, J2405, J2425, J2430, J2469, J2505, J2765, J2780, J2783, J2820, J2920, J2930, J3240, J3250, J3315, J3410, J3487, J8501, J8510-J8521, J8530, J8540, J8560, J8565, J8597, J8600, J8610, J8700, J9000-J9097, J9098, J9100-J9190, J9200-J9293, J9300, J9305, J9310, J9320-J9390, J9395, J9600, Q0163-Q0181, Q2017, S0023, S0088, S0091, S0108, S0145, S0146, S0156, S0170, S0172, S0174, S0175, S0176, S0177, S0178, S0179, S0181, S0182, S0183, S0187
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|
- A.
- Antineoplastic Agents
|
- A.
- Antineoplastic agents which have FDA approval are covered when supplied by a doctor and given by an eligible method of administration.
- NOTE:
- Antineoplastic agents administered in a hospital/facility setting are reimbursed to the facility, unless the cost of the agent is incurred by the doctor.
|
- B.
- Other Drugs
|
- B.
- Coverage for other drugs is determined according to individual or group customer benefits.
Payment should be made for prescription drugs which are ordered and dispensed by a doctor and which relate directly to the treatment of malignant disease.
-
Chemotherapy should be provided for drugs administered as part of a rescue from, or antidote for, severe toxic reactions to the antineoplastic agent, e.g., Leucovorin given as an antidote following high-dose Methotrexate therapy; diuretics with CisPlatin; or antiemetics.
Payment may be made for oral antiemetic drugs (Q0163-Q0181) when used as full replacement for intravenous antiemetic drugs as part of a cancer chemotherapeutic regimen. Procedure codes Q0166 and Q0180 should not exceed a 24 hour dosage regimen. The remaining codes should not exceed a 48 hour dosage regimen.
Payment should not be made for a rescue agent that is provided in conjunction with the administration of an ineligible antineoplastic drug. In addition, drugs prescribed as dietary supplements, vitamins, sedatives or non- prescription drugs such as aspirin are not covered.
|
- II.
- Methods of Administration
(50391, 51720, 90760, 90761, 90765-90775, 96401-96450, 96521, 96522, 96523, 96542)
|
|
- A.
- Subcutaneous, intra-muscular, intravenous or intra-arterial injection, infusion or perfusion and intracavitary (e.g., instillation into the bladder via catheter).
|
- A.
- Coverage is determined according to individual or group customer benefits.
When multiple drugs are administered concurrently by the same route of administration, only one administration fee will be paid.
When multiple drugs are given sequentially or by different routes of administration, a separate fee will be paid for each administration. This includes rescue agents, etc., described in section I.B. The appropriate administration code should be reported.
NOTE: Instillation of an anti-carcinogenic agent into the bladder (code 51720) is a covered surgical service.
Instillation(s) of therapeutic agent into renal pelvis and/or ureter through established nephrostomy, pyelostomy, or ureterostomy tube (e.g., anticarcinogenic or antifungal agent) (code 50391) is a covered surgical service.
|
- B.
- Topical
|
- B.
- Covered as chemosurgical destruction of a malignant lesion when the antineoplastic drug must be applied by the doctor. For chemosurgical destruction, report code 96549.
If the drug is reported on the same day as the topical administration of chemotherapy, and the charges are itemized, combine the charges and pay only the topical administration of chemotherapy.
Payment for the topical administration of chemotherapy performed on the same date of service includes the allowance for the drug. A participating, preferred, or network provider cannot bill the member separately for the drug in this case.
If the drug is reported independently, process it under the appropriate code.
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NOTE: The method of administration is covered only when the drug is eligible for payment. |
- III.
- Adjunctive Services
|
|
- A.
- Medical care including observation and examination
|
- A.
- Generally payment can be made for medical care in conjunction with or as follow-up to chemotherapy provided on an outpatient basis.
|
- B.
- Surgery
|
- B.
- Eligible
When drugs are administered into a cavity, e.g., lumbar puncture, peritoneocentesis or thoracentesis, payment will be made for the drug.
However, since the surgical procedure is considered a route of administration, a separate administration allowance will not be made.
|
- C.
- Hydration Therapy
(J7030, J7040, J7042, J7050, J7060, J7070)
|
- C.
- Hydration therapy is considered a rescue agent when it is used in conjunction with chemotherapy. When hydration therapy is used for indications other than as a rescue agent, it is subject to the member's therapeutic injection benefit coverage. If the rescue agent is not a benefit of the member's contract, it is not covered. In this instance, a participating, preferred, or network provider can bill the member for the denied service.
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- D.
- Other type of service such as pathology, radiology, etc.
|
- D.
- Payment is made for medically necessary services.
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- E.
- Supply charges (e.g., needles, swabs, bandaids, tubing, etc.) but not limited to, those listed
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- E.
- Supplies used in the administration of chemotherapy are considered part of a provider's expense. Coverage for such expenses is determined according to individual or group customer benefits. A participating, preferred, or network provider cannot bill the member for these expenses.
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Any program variations to the chemotherapy benefit are identified according to individual or group customer benefits.
See Medical Policy Bulletin I-7 on Erythropoietin (EPO).
See Medical Policy Bulletin I-13 on Interferon Alpha.
See Medical Policy Bulletin I-16 on Leuprolide (Lupron).
See Medical Policy Bulletin I-21 on Herceptin. |